Our findings indicated that GL13K-Ti partially inhibited osteoclastogenesis and expression of osteoclast-related genes and proteins by limiting the formation of the actin ring, an important structure ...
uk-erlangen.de Objectives Autophagy has recently been shown to regulate osteoclast activity and osteoclast differentiation. Here, we aim to investigate the impact of autophagy inhibition as a ...
Also, staining of tissues with anti-RANK antibodies showed a gradient of RANK+ cells (presumably osteoclast precursors) increasing in number from the blood vessels in the subsynovium to the ...
Total Revenues in the first nine months of 2024 increased by $300 million compared to same period in 2023, to $339 million, with Q3 revenues contributing $103 millionProduct revenues in the first nine ...
During menopause, estrogen levels decline, leading to a spike in osteoclast activity (bone loss). As a result, bones are broken down more quickly than they’re rebuilt, and they become weakened ...
The past decade has seen significant advances in our understanding of skeletal homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent breakthroughs have arisen ...
Osteolytic diseases, such as osteoporosis, rheumatoid arthritis, osteosarcoma, and giant-cell tumors of bone, are characterized by increased bone resorption and decreased bone formation, leading to ...