Both of these reports lacked pH measurements and interpretation of drug structures and pH and pKa ... acid OH groups are replaced to make the disodium salt. f One COOH group on succinic acid ...

Most organic drugs contain one acid group, usually a carboxylic acid, -COOH, or one basic primary, secondary, or tertiary amino group, NC 1-3, [3,22,27,28,29] that determines the acid-base ...