【导读】针对肿瘤特异性新抗原的免疫治疗具有潜力，但它们在肿瘤细胞上的超低表达，对T细胞治疗提出了挑战。在这项研究中，团队发现，嵌合抗原受体（CARs）在针对人类白细胞抗原（HLA）I类呈现的p53R175H新抗原时，其敏感性比T细胞受体（TCRs）低 ...

Trinity College and the University of Cambridge will provide £48 million over 5 years to fund around 30 PhD students ...

T cells use T cell receptors (TCRs) to identify and eliminate diseased cells. T cells equipped with cancer-targeting TCRs can detect and eliminate cancer cells, and TCR-based T cell therapies have ...

2024年10月16日，专注于肿瘤和自免疾病通用型γδT细胞疗法的上市公司Adicet ...

This award allows us to begin a clinical trial to treat five patients with this new TCR construct that improves on what we ...

Besides demonstrating that there is no intrinsic structural block to generating high-affinity TCRs, the findings could have implications for a variety of clinical applications. The approach ...

The presentation ”Seamless Integration of a Universal Epitope into Recombinant TCRs for Tagging and Tracking of TCR-T Cells Expressing 3S TCRs” and the poster “UniTope & TraCR – A universal tagging ...

"Among other factors, the success of TCR-guided therapies for solid tumors hinges on several key innovations: developing optimal TCRs that are safe, sensitive, and specific; enhancing engineered cells ...

The University of Cambridge said the Trinity Cambridge Research Studentships (TCRS) have been created to respond to declining ...

The University of Cambridge and Trinity College have announced £48 million in fully funded PhD programmes. In response to ...

By combining these TCRs with different components of the immune system such as T cells, natural killer (NK) cells or a CD3 complex (TCE, T cell engager), highly specific, sensitive and safe modalities ...