A cortical tri-culture model advances the validation process in neurodegenerative drug discovery, offering new possibilities ...

KPV细胞的谷胱甘肽过氧化物酶4（GPX4）水平降低，导致有毒的脂质过氧化物的积累和铁萎缩增加。总之，我们的结果表明，在NSCLC中，vimentin是肿瘤快速生长、转移和保护铁蛋白的必要条件。 胰腺导管腺癌（PDAC）是一种高度致命的癌症，通常表现出对化疗的耐药性。

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The authors investigate the mechanism behind the widely observed but poorly understood phenomenon of reversible vimentin disassembly upon hypotonic challenge. Using permeabilized COS-7 cells ...

As with most intermediate filament systems, the hierarchical self-assembly of vimentin into nonpolar filaments requires no nucleators or energy input. Utilizing a set of live-cell, single-molecule, ...

Expression of α-basic-crystallin – Expressed in approximately 50% 33 Increased versus other intrinsic types * BLBC—variously defined (that is not restricted to tumors defined on gene ...