FZD6, ITGA3 and CAV1 were the most significantly upregulated miR-199a/b-5p targets in MSCs during chondrogenesis. Multiple mRNA targets of miR-199a/b-5p are likely regulated during chondrogenesis. To ...

The differentiation process of MSC is regulated by various molecules among which Sox9 and Runx2 are key transcription factors leading, respectively to chondrogenesis or osteogenesis. Recently, a new ...

Four of the biological processes involved in the fracture healing process were implemented: chondrogenesis, cartilage calcification, intramembranous ossification, and endochondral ossification.

90. Reeck JC, Hardy MJ, Pu X, Keller-Peck C, Oxford JT. Authentication of a novel antibody to zebrafish collagen type XI alpha 1 chain (Col11a1a). BMC Res Notes. 2021 Sep 15;14(1):359. doi: ...

Innovative JAGGED1-based therapies show promise for pediatric craniofacial bone loss, potentially overcoming limitations of current treatments with more effective and accessible solutions.

Cartilage development is the formation of cartilage by specialised cells called chondrocytes. These secrete large amounts of the cartilage extracellular matrix, which contains collagen and ...

The main finding of the study by Sommar et al. 1 is that human dermal fibroblasts, isolated by way of a relatively simple procedure, have the ability to differentiate in vitro into osteoblasts and ...

1 School of Mechanical Engineering, Dalian Jiaotong University, Dalian, China 2 Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China Objective: To investigate ...

SMART researchers have developed a novel method, including the application of a process analytical tool, that can be used to improve the efficacy of mesenchymal stromal cells (MSCs)-based therapy ...

Interventions targeting these pathogenic factors may contribute to the treatment of OA. MiRNAs are single strand non-coding small RNAs, which are regulated in chondrogenesis and OA[2,3]. Recent ...

Diffuse idiopathic skeletal hyperostosis (DISH) is a well-recognised entity characterised by calcifications and ossifications of the entheses affecting mainly the spine and peripheral sites. DISH is ...