BACKGROUND: Endothelial cells (ECs) use glycolysis to produce energy. In preclinical models of peripheral arterial disease, further activation of EC glycolysis was ineffective or deleterious in ...

Finally, decreased GAPDH activity activates the polyol pathway, increases intracellular AGE formation, activates PKC and subsequently NFκB, and activates hexosamine pathway flux. If hyperglycemia ...

FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during ...

Although differentiation and activity of bone-forming osteoblasts are regulated at various levels, there is ample evidence ...

Because reactive oxygen species are produced via oxidative phosphorylation during anaerobic glycolysis, via the Schiff reaction during glycation, via glucose autoxidation, and via hexosamine ...

1 ChimNutra Labs, Department of Pharmacy, University of Naples Federico II, Naples, Italy 2 Department of Pharmacy, University of Naples Federico II, Naples, Italy The management of allergic events is ...

1 Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China 2 Institute of Interdisciplinary Integrative Medicine Research, ...

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The untranslated regions (UTRs) of mRNAs harbor regulatory elements influencing translation efficiency. Although 3.7% of disease-relevant human mutations occur in UTRs, their exact role in ...