Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated ...

The study emphasises on the role of the p53 tumor suppressor gene in the pathogenesis of ulcerative colitis - an inflammatory bowel disease.

The findings offer a promising drug target to prevent progression to colon cancer by targeting abnormal cells early on.

Results provide a mechanistic explanation of why early loss of p53 signaling is frequently observed in UC-associated ...

New research highlights a pivotal role for the p53 gene in ulcerative colitis progression, offering a potential therapeutic ...

In a recent perspective published in the journal Cell Death and Differentiation, researchers in France, Germany, and Sweden ...

德国Max delbrck中心Michael Sigal实验室和柏林慈善医院的研究人员在《科学进展》杂志上发表了一项研究结果，阐明了p53基因在溃疡性结肠炎中的作用，提出了一种潜在的新药靶点，可以阻止疾病发展为癌症。

It causes mutations in the p53 tumor-suppressor gene as well as ras mutations, which are involved in the majority of human cancers. Aflatoxin has been shown to contaminate tobacco products.

In the presentation titled, "Oncogenic human papillomavirus hijacks p300 to drive viral transcription, creating a therapeutic vulnerability that can be exploited with selective p300/CBP catalytic ...

Presentation Details: Title: CLSP-1025, a novel bispecific T cell engager targeting a p53 R175H mutant peptide presented by HLA-A*02:01 Presentation Type: Poster Abstract Number: 1061 Date and ...

Enrollment on track in registrational Phase 2 portion of PYNNACLE clinical trial evaluating rezatapopt as monotherapy in patients with TP53 Y220C and KRAS wild-type advanced solid tumors; more than 75 ...

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more advanced form, metabolic dysfunction-associated ...