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The EMBO Journal
8 小时
Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ ...
To address the unmet need for a cure for RTT, the therapeutic potential of adult Neural Precursor Cells (NPCs) was ...
The EMBO Journal
18 小时
SUMOylation of protein phosphatase 5 regulates phosphatase activity and substrate release
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The serine/threonine protein phosphatase 5 ...
The EMBO Journal
8 个月
TBK1-Zyxin signaling controls tumor-associated macrophage recruitment to mitigate antitumor ...
Although the role of innate immune sensing pathways is well-studied in the pathogenesis of malignancies, whether they ...
The EMBO Journal
1 天
Liver protects neuron viability and electrocortical activity in post-cardiac arrest brain ...
The liver function in post-cardiac arrest brain injury is not known and was investigated in a pig model of global cerebral ...
The EMBO Journal
1 天
Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction
Astrocytes in the brain exhibit significant regional diversity, but the mechanisms controlling their heterogeneity remain ...
The EMBO Journal
1 天
A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
Mice express full-length protein ZBP1-L as well as an alternatively-spliced shorter isoform (ZBP1-S) containing only its two ...
The EMBO Journal
2 天
Acetylation of TIR domains in the TLR4-Mal-MyD88 complex regulates immune responses in sepsis
Activation of macrophage TLR4 by bacterial endotoxins is important for the progression of sepsis, but the underlying ...
The EMBO Journal
2 天
miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...
The EMBO Journal
4 天
RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation
MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...
The EMBO Journal
4 天
RNA fine-tunes estrogen receptor-alpha binding on low-affinity DNA motifs for ...
RNA modulates transcription factor binding to DNA, though the subsequent effect on transcription remains unclear. The study ...
The EMBO Journal
7 天
Glutaminolysis provides nucleotides and amino acids to regulate osteoclast differentiation ...
Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...
The EMBO Journal
4 天
IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis ...
How the hydrolytic activity of mitochondrial ATP synthase is modulated during brown adipose tissue (BAT) thermogenesis ...
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