President Joe Biden warned Wednesday that “all-out war is possible” in the Middle East, acknowledging the limits of his own persistent diplomatic efforts at achieving a cease-fire deal.

The war in Gaza has endured more than 11 months, and violence between Israel and Hezbollah, the Iranian-backed Lebanese militia, has risen sharply over the last week.

This is one of Biden’s final opportunities to tout his foreign policy legacy on the world stage, but the focus is likely to be on an escalating conflict.