了解天然稳定酶的热稳定机制，提高不稳定酶的热稳定性是酶工程研究的重要内容。尽管现有的蛋白质设计工具和深度学习技术取得了一定的进展，然而准确预测突变对蛋白质热稳定性的影响仍然充满挑战。近日，中国农业科学院姚斌院士团队涂涛组和杭州力文所王浩博博士团队合作 ...

Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular ...

School of Food and Biological Engineering, Anhui Fermented Food Engineering Research Center, Hefei University of Technology, Hefei 230601, China ...

Williams, R. J. P., in “The Enzymes”, edit Boyer, P. D., Lardy, H., and Myrbäck, K., 1, chapter 9, p. 391 (Academic Press, New York, 1959).

ProtSSN is a valuable approach that generates protein embeddings by integrating sequence and structural information, demonstrating improved prediction of mutation effects on thermostability compared ...

ProtSSN is a valuable approach that generates protein embeddings by integrating sequence and structural information, demonstrating improved prediction of mutation effects on thermostability compared ...